456 Hereditary Angioedema: Report of Ten Mexican Patients at West National Medical Center in Guadalajara City

of the attacks. Safety was assessed in terms of adverse events. All participants gave written informed consent. Results: There were 21 acute attacks, 14 for icatibant and 7 for FFP. The median time to onset of symptoms relief was 27 and 45 minutes for icatibant and FFP respectively (P 1⁄4 0.106). The median time to complete resolution of all simptoms was 240 and 2880 minutes respectively for icatibant and FFP (P 1⁄4 0.002). All patients with Icatibant experienced generally mild transient injection-site reactions (erythema and swelling, and pain) wich resolved spontaneously without intervention. No drug-related serious adverse events were observed with icatibant and administration of FFP was not associated with infections of human inmunodeficiency virus, or hepatitis virus. Conclusions: Icatibant was effective and generally well tolerated, providing rapid regression of symptoms associated with acute HAE attacks at all anatomic sites.